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ea0044p13 | Adrenal and Steroids | SFEBES2016

Characterization of clinical, biochemical and adrenal hormonal effects of ATR-101, a selective ACAT1 antagonist, in dogs with naturally-occurring Cushing’s syndrome

Hunt Stephen , Fritz Michele , Schall William , Bari Olivier N. , Smedley Rebecca , Pearson Paul , Bailey Marc , Langlois Daniel

Cushings syndrome (CS) in humans shares many similarities with its counterpart in dogs in terms of etiology (pituitary versus adrenal causes), clinical signs, and pathophysiologic sequelae. ATR-101 is a novel small molecule therapeutic currently in clinical development for the treatment of congenital adrenal hyperplasia and adrenocortical carcinoma in humans. ATR-101 is an adrenal-selective inhibitor of ACAT1 (acyl coenzyme A:cholesterol acyltransferase 1). ACAT1 catalyz...

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Endocrine Abstracts

Characterization of clinical, biochemical and adrenal hormonal effects of ATR-101, a selective ACAT1 antagonist, in dogs with naturally-occurring Cushing’s syndrome

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